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Can Serotonin Levels Replenished

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As the title suggests, I want to know if Serotonin levels can be replenished.

What I mean is, lets say my friend did street Ecstasy, which contained not only MDMA but cocaine as well as heroin, for about 6 months, every single day and moreso on the weekends.

He now has a mood deficiency where his moods fluctuate all over the place. He was prescribed different drugs such as Seroquel and the newer one Ibilify, but because of an incident, he was taken off.

I know something about Ecstasy (actual Ecstasy, MDMA) has something to do with screwing with serotonin levels. If I'm not mistaken, Ecstasy reaches into the pool of serotonin (in so many words, I'm not looking for wikipedia accuracy here) and from there, I don't know.

I know of other people, not just my friend, who did Ecstasy and some of them are on hardcore amounts of anti-depressants. So my question is, for my friend, is there anyway that his levels of serotonin will reach normal so he can be remotely happy again on a day-to-day basis?