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Why wont my computer let me click on things?

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My computer wont let me click on the icons like internet explorer msn etc...it also wont let me click on the desktop. Also sometimes it will completely lock up on me. The only time I can get on the internet is if I logoff my computer by pressing ctrl alt dlt and signing in again and for about 20 seconds it lets me click on things then I can run my internet. also if I click on a new tab it freezes my internet. also at the bottom bar where it tells what programs your running I cant click that and if I minimize my window it wont come back again so whats wrong??