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My Mom is Manic Depressive and talks to me with distain and disgust

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She always looks for something to pick at me....All she does is stay in her room everyday 24/7 and is on meds.My son comes for weekends and she still stays in room....It makes me sad im 29 and we are helping each other my dad helping me while i go to school..and mom just swears ,says im not a good father when I am and she talks to me and picks for nothing.Like my grandmother died 1 1/2 years ago and she is carrying some kind of burden...Look she just did it.I mean all day everyday.Dragging me in a a depression.What do I do