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A single-family home is a house designed to have only one family live in it. A multi-family home is a house (not an apartment building) designed to have more than one family living in it, in separate units (like apartments) within the house. For example, a three-flat or triple decker would be a three-story house in which each of the three floors is a separate living unit unto itself, one on top of the other. There are, of course, many other multi-family home designs, too.