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It’s hard to answer this subjectively as it really depends on the sufferer. The severity of the symptoms can range dramatically from one person to another. They can also vary from day to day, month to month, and year to year. Generally, the most debilitating symptom is extreme tiredness and a general feeling of unwell. For some people, this won’t interfere with their day-to-day lives, and they may just need more rest than people who don’t suffer from CFS. From others, it can mean being bedridden for large portions of the day and can interfere with their working life, family life, and social life. However, for sufferers who find that CFS is seriously debilitating, it is possible to explore treatments to minimize their symptoms and make it easier to live with the condition. Medication and exercise programs can help, and there are lots of alternative CFS ME treatment options out there which can be even more effective at alleviating symptoms. I hope this helps!