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Virus overload

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My sister in laws computer is absolutely infested with viruses. She bought it used, but she paid a good price for it. When she bought it, it was already infected with viruses. I'm trying to fix it for her, but I'm beyond knowing what to do at this point. The homepage goes to something about internet security and it tells me what I need to download, but I'm not crazy about downloading any kind of antispyware that I dont know about. A man I work with suggested that I download avast. Does anyone else have any suggestions on what to do?